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Biology 3d printing
What is 3D Bioprinting? | Bioprinting Explained
“3D Bioprinting” or “bioprinting” is a form of additive manufacturing that uses cells and biomaterials instead of traditional metals and plastics to create 3D constructs that are functional 3D tissues. These biomaterials are called bioinks, and they mimic the composition of our tissues. Bioprinting can be applied to a variety of areas including but not limited to regenerative medicine, drug discovery and development, and 3D cell culture.
A 3D construct bioprinted on an Allevi by 3D Systems bioprinterBioprinted structures, such as organs-on-chips, can be used to study functions of a human body outside the body, in 3D. The geometry of a 3D bioprinted structure is more similar to that of a naturally occurring biological system than an in vitro 2D model. Structural similarity can in turn lead to functional results that are more physiologically relevant. No other technology enables the level of geometric complexity in engineering tissues that 3D bioprinting enables. That is why this technology has the potential to completely change the way we treat diseases – by replacing animal testing and ending the organ transplant waiting list.
How does 3D bioprinting work?
3D bioprinting starts with a model of a structure, which is recreated layer-by-layer out of a bioink either mixed with living cells, or seeded with cells after the print is complete. These starting models can come from anywhere – a CT or MRI scan, a computer generated design (CAD) program, or a file downloaded from the internet.
That 3D model file is then fed into a slicer – a specialized kind of computer program which analyzes the geometry of the model and generates a series of thin layers, or slices, which form the shape of the original model when stacked vertically. Cura and slic3r are examples of slicers commonly used in 3D printing. Allevi also has a specialized slicer, optimized specifically for bioprinting, built into our Allevi Bioprint software.
Once a model is sliced, the slices are transformed into path data, stored as a G-code file, which can be sent to a 3D bioprinter for printing.
The bioprinter follows instructions in the G-code file in order, including instructions to control for temperature of the extruders, extrusion pressure, bed plate temperature, crosslinking intensity and frequency, and, of course, the 3D movement path generated by the slicer. Once all of the G-code commands are completed, the print is done and can be cultured or seeded with cells as part of a biostudy.
Why is bioprinting important?
Over 120,000 people in the US alone are on waiting lists for organs, and others experience chronic problems due to the long-term damaging effects of post-transplant immunosuppression. There is a large and growing need for an alternative to the organ transplant waiting list.
The scientific community has already succeeded in bringing together multidisciplinary teams of researchers, physicians, and engineers to take on the biggest challenges to human health, and 3D bioprinting is an exciting new tool with the potential to eliminate the organ transplant waiting list.
For pharmaceutical development, 3D bioprinting offers a means of testing drugs faster, at a lower cost, and with better biological relevance to humans than animal testing. In the biomedical devices field, 3D bioprinting has enabled new developments such as sugar stents to help surgeons join veins with fewer complications, and systems for improved drug delivery, among others.
As bioprinting evolves, it will become possible to use a patient’s own cells to 3D print skin and bone grafts, organ patches, and even full replacement organs. Personalized and regenerative medicine continue to grow in popularity, and 3D bioprinting will give doctors and researchers the tools to better target treatments and improve patient outcomes.
Further reading
Bioprinting 101 – Allevi
3D Bioprinting – Wikipedia
3D Bioprinting of Living Tissues – Wyss Institute, Harvard
Bioprinting – NIH Director’s Blog
🧪Best print files 3D printed for biology・Cults
🧪Best print files 3D printed for biology
Download 3D files of props for biology classes
Discover a selection of the best 3D printable files to be made with a 3D printer in Earth Science and Life courses. You will find useful accessories in a laboratory, but also educational projects around biology and geology.
To Make or not to Make
Free
Anatomical Skull
Free
Multi-Color Cell Model
Free
Coronavirus Covid-19
Free
Heart Shaped Box
Free
Multi-Color Mini Plant Cell
Free
The golden heart
Free
3 colors Anatomical Heart
Free
Giant Hollow Two Color World
Free
Bacteriophage - T4 Virus
Free
Reprap Double Helix
Free
Inner Solar System
Free
Low-Cost Opensource Mechanical Ventilator
Free
Trilobite (P149623)
Free
Female Anatomy Reference
Free
Gale Crater, Mars
Free
Falcon Tube Rack for 50mL and 15mL
Free
DNA Molecule
Free
Multi-Color Earth Core Model
Free
Femur Bone with Stand
Free
Fluid-Filled Vestibular Apparatus
Free
Mount Everest
Free
DIYbio Lab Block
Free
Parametric Sample Carrier
Free
Comura Articulatum
Free
Multi-Color Caffeine Molecule Model
Free
The Educative Eardrum
Free
DIYbio Centrifuge V 2.
0Free
Double helix challenge
Free
DNA/RNA Building Toy Set with Improved Joints
Free
Modeling Topography and Erosion with 3D Printing
Free
fructose molecule
Free
POLLEN SPORES
Free
Molécule d'ADN - DNA molecule
Free
Coronavirus, optimized HI-RES (COVID-19)
Free
Solar System Education Kit
Free
DIYbio Centrifuge V 3.0
Free
Vestibular Apparatus Education Model
Free
Crickit Lab Shaker
Free
Test Tube Support (Small)
Free
Magnetic Stirrer + Stir Bar
Free
chemistry and biology kit
Free
Magnetic Stirrer V2
Free
Amoeba LED Lamp-V1
Free
Bacteriophage
Free
Test tube stand for up to 7 normal sized test tubes
Free
stand for up to 7 large test tubes
Free
Nemoriko´s : Chemie Schablone - Chemistry template pattern
Free
Here is our selection of the best STL files for Biology and Geology courses, all these accessories are from the Library of 3D files Cults and are easily 3D printable.
This collection gathers free 3D files of accessories for Earth Science and Life Sciences (ESL) teachers. These very varied 3D models cover almost all the fields covered in biology and geology courses or simply during practical laboratory work. There are many examples of molecules, cells, viruses, microbes, DNA and other bacteria, these representations will allow students to perfectly understand their shape. Everything related to the human body is present in this selection, there are skulls, bones or reproductions of vital organs (liver, lungs, heart...).
The geology classes will not be outdone because there are also very beautiful models of the earth and other planets as well as 3D printable topographic map (there is a collection dedicated to this subject).
More concretely, you will also find useful accessories for laboratory workers and during practical work. There are test tube holders, microscope slide holders, pliers.
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This collection is the proof that a 3D printer is not only dedicated to rapid prototyping. In the context of the colleague or high school and especially in Biology and Geology classes, it is an excellent educational tool. Its use brings an educational but also playful aspect and can be used to create bridges between Biology and Technology courses.
If you are a teacher and you have 3D models used in your classes, don't hesitate to share them directly on Cults so that as many people as possible can benefit from them. We would also be very interested in feedback on the models in this selection. So don't hesitate to post your Makes and tell us how you use them in your classes.
Biological merch or not an extra way to use a 3D printer / Habr
Good day, dear inhabitants of Habr.
I have been reading posts here for a long time on various issues, mainly related to my hobbies or interests, not at all related to either hobby or professional activity.
Yes, I forgot to introduce myself.
Mila, very nice. A biologist by education, a biotechnologist by profession and a tower, by interests... Well, it's hard to say.
My interests are very diverse - from drawing anatomical illustrations to crocheting. In most hobbies, I try to maintain a balance, more or less evenly mastering various branches of art. I don't differentiate between traditional pencil and brush drawing, drawing on a graphics tablet in Photoshop, real-time modeling in clay and plastic, or using 3D software packages - to me, it's all art. Sometimes I even successfully combine everything at once in one project.
But in recent years, 3D modeling has come to the fore more and more.
Only this is not modeling complex technical elements using AutoCAD and similar tools. Although I also have this:
V-22 Osprey tiltrotor. Low-poly blank of many years ago, sawn to look like an indie toy that was not destined to come out) But I don't like sawing technique, I'm still a biologist.
Organics and modeling is my theme. And I inherited artistic skills - my mother is also an artist.
It just so happens that since childhood I have loved two things: drawing and science. And I just can't quit and leave something alone. We have to combine pleasant and useful.
- Would a biologist need the skills of a draftsman? - you ask.
- How else, - I will answer.
What is it? For example, in species recognition. The phone may sit down at the most crucial moment, but the pencil and paper will not let you down.
I am really proud of the birds drawn in the park in the autumn of 2015 in zoological practice. I didn’t have time to finish the woodpecker - it started to rain, and I had to urgently hide the watercolor.Yes, and in principle it's nice to just sit, meditate in the park, feel like a part of nature, and draw everything that comes into view.
The colors have faded over the years and even "spread" a little on not too artistic paper, but the crumbling is still good.
Same 2015. In addition, my drawing skills helped me a lot in microbiology. Try to draw an unknown garbage under a microscope in less than half an hour under three conditions:
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you see it for the first time and don’t understand what it is at all (although I just understood)
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an old, Soviet, light microscope, and only a mirror as a light source, because The lamp is broken. And knock down the settings - time to lose.
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the tube with the eyepiece is very long, and the slightest shift of the eye already deprives you of the opportunity to see the transparent colorless nonsense that you need to draw during the lesson. And better faster - the next pair in the building, to run to which about 8 minutes on ice. Quest, however!
In addition, biological drawing can be used for public benefit. For example, at one time I was fond of making educational methodical cards.
Besides, there is such a thing as reconstruction. I think many people came across it when they opened the atlas with dinosaurs. To do this, you need to be a very talented artist, and at the same time understand anatomy. Yes, not in a simple, but in a comparative one: the reenactor must know which bone in the body of which animal performs what function, which protrusions and depressions on it are responsible for what, and how they can be attached to each other so that the animal can move. But I will also someday make a separate post about this - there are too many subtleties.
But, of course, the matter was not limited to sketches of animals. Imagination has always trailed the craving for knowledge of the world, and, naturally, the desire to transfer this very imagination into life, even in a drawing.
Biology also came in handy here.
Yes, you can follow the path of surrealist artists, and simply and thoughtlessly mix pieces and images of animals and objects, putting a deep allegorical meaning. But no.
The fact is that a person has some idea of the "correctness" of the surrounding world. No, I'm not talking about a divine spark, although you can call it that, and not about "universal standards of beauty", which cannot be by definition. I'm talking about what the artists of Antiquity and the Renaissance called the golden ratio.
It just so happens that nature (God, natural selection, universal mind - whatever) selects the most effective forms for everything that composes it. And it so happened that most of these forms fit into some regularities. Our brain analyzes them, and we consider the most consistent with these patterns, as well as the closest to the familiar and familiar, to be more attractive.
In other words, even a fantasy monster, drawn in accordance with the laws of biology, looks more pleasing to the eye than a mindlessly molded chimera.
Here are some examples.
Combining the features of lizards, dinosaurs and large sauromorphs, as well as adding a pinch of fantasy, we get a more or less anatomical, and, moreover, quite nice dragon. Unless the ears are fiction, science does not know exactly what shape and length they were, but they are definitely longer than those of a lion) And even a cartoon created with a bit of biologicality looks quite pleasing to the eye. The model was made to order according to the reference. The customer was satisfied.Biological is not a term. I simply designate by this word a set of details that in one way or another correspond to certain laws of biology. For example, the eyes are well-made, mobile and detailed, they perform an important function - they make the model or picture come alive.
Another character to order - a cat-dog-dragon, in fact, it also differs little from the animal lizards above. On the render, the wet shine of the eyes is hard to see, which gives liveliness when working with the animal itself and its movements.
I'm really proud of my facial expressions. Perhaps only laziness and an absolute lack of talent for coding stopped me from making my own toy with such monsters. P.S. Yes, many years ago I posted this picture on the couch, but now I can't find it without a watermark) Of course, every art has its problems. For example, when I make to order (and I also make art and models to order), the customer often does not imagine what he wants, giving very vague instructions. And after doing most of the work, he needs to redo it, since a more harmonious one does not suit him, suits him like that ... but how and what suits - he himself does not know. So we have to give up biologicalness in favor of the momentary whims of a person who will change his mind tomorrow.
Another problem - because of some rigidity (what to do - professional deformation) it can be difficult for me to look at other people's creations. And both from an artistic and biological point of view. Especially when a person justifies all the jambs with anatomy and quality "with his own style.
" You draw without a year a week, what style?!
*at this moment slippers should fly at me at the first cosmic speed*
But that's not what this post is about. And there is not so much about the fact that biological merchandise - it doesn’t matter, 3D or any other. And the one that can be found, for the most part, does not differ in either quality or biological content. And even it contains the grossest errors on all fronts - both in quality, and in science, and in the artistic part.
The maximum that can be found everywhere - children's sets with dinosaurs.
Joke.
There are also personal projects and merch of popularizers from among bloggers.
So, for a long time, I have been nurturing the idea of biological propaganda by creating every little thing, even key chains. And finally, there was such an opportunity.
Concurrently, I am now one of the admins of the popular science public. If you want, consider it an advertisement, but is it right to consider an admin's post about your work as an advertisement?
That's where my skills came in handy - both as a biologist and as an artist.
We are slowly sawing informative, educational and entertaining (and all this at the same time) content using a variety of approaches.
But popularization is a special path. Everything served under this sauce should be not only scientific and accessible, but also interesting, fun and, most importantly, useful. And this is the most difficult thing - to combine it all into a concise single form.
Start simple. Now in development are several types of key chains of different detail and with different symbols, in terms of stands and T-shirts with various fossils. Some of them are ready or almost ready.
For example, the European bison. The last letter O is a hole for attaching a key chain or ringYes, I will use the words "keychain", "keychains" instead of "keychain", "keychains", because at the time of my childhood there was no corresponding correction in the dictionary, and both forms were legitimate in use :-)
The contour for the bison was "drawn" by hand with the polygon creation tools.
Some unpleasant things emerged from this, such as inverted polygons and double vertices, since the internal tools of the program do not always allow you to control every step and notice errors in time. Plus, my computer doesn't shine with novelty and freshness - it's far from being a gaming machine :-)
Search solutions were difficult. How exactly the bison should look, how stylized it will be, and where the ring should be - was decided by the whole team)
The thickness of the keychain and the size of the text are also importantAs a result, the keychain meets all the requirements:
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it is scientific, that is, it corresponds to the essential biological characteristics, reflects the phenotype of the animal, and also contains the Latin specific name
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it is interesting for its shape, unusualness and style. Artistic performance in the form of a hybrid of a flat stylized image and at the same time volume - definitely attracts attention.
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he is useful. Let its function be quite simple: like the Nutcracker is designed to crack nuts, the bison is just a keychain or a decoration for a bag. But thanks to its form, it is now also an instrument of knowledge and an individualizing accessory.
That's how many useful things! And it's just a keychain.
But if everything is more or less clear with stylization as a 2D vector image, then there were difficulties with creating another keychain. Not in terms of execution, although the zebra sometimes kicked around corners, but in terms of the appearance of the animal.
In the early stages, individual details were very different. To roughly understand what kind of animal this is, this is the Shield, also known as the Tri-eye ( Triopsidae ). Taxonomically, this is a branchial crustacean that usually lives in temporary (drying) water bodies and is very widespread. If you have never seen these beautiful creatures - do not worry, most of them are only a few centimeters in size (different types are from 2-3 to 15 cm).
Outwardly, they are very different, as you can see for yourself.
The shape of the shell, the location of the eyes, tail segments and legs - find a hundred differences :-) Some, like paws, were then duplicated. Some have undergone major modifications, such as retopology. Although in the end result, an inexperienced eye will not notice the entire magnitude of the work. Sometimes it's easier to detect jambs in the fill mode)In the end, we settled on this option for the time being - the middle one between modern and fossil species.
All parts are merged, but the work is not finished yetBut that's not all. The combined model still needs to be checked for errors - holes, intersections, visual deviations, etc. This is partly done in the zebra itself, partly in other, specialized programs. In addition, I like to wield renders.
It's very funny sometimes to play with shaders and see how the model will look printed in non-standard materials This is not an idle whim - sometimes it helps to see completely inconspicuous things.
Like, for example, irregularities after merging and trimming the figure
However, the work does not end there either - not a single model is made in a single version, especially a search one. So this crustacean will still have to serve as a field for experiments - whether to make a relief on the "bottom" and how to make it - the logo of the public or the paws of the crustacean itself?
Default shader - matte plasticYes, and the material of the keychain is still the subject of much thought - after all, you need to take this into account in further work: what and how much to detail, whether to make cavities or cut for ease of printing, plan support, like in dances .... For the first time, it is planned to fdm- plastic, but what kind - I don’t understand this, since I don’t have my own 3D printer yet. But I'm working on it.
I hope my acquaintance with Habr will be long and fruitful.
All the best!
P..jpg)
S. I don't know if it's necessary to put tags and which ones. In general, I will accept any feasible help in mastering the article writing on Habré.
experiments with appearance / Sudo Null IT News
Good day, dear habrazhiteli!
Last time I told you about how biology and 3D modeling can help each other by developing and developing skills both biological and artistic. If you missed it, you can read here https://habr.com/ru/post/573970/
Key chains with the brand name of the popular science project and biological information about the animal, whose appearance served as the prototype of the key chain, were also announced there.
Vector volume and plastic shader. The quality is poor, but it looks good anyway. The first key ring - European bison ( Bison bonasus ), is waiting for its serial printing. Visually stylized as a vector image, on the left side - the Latin name, on the right - the name of the community. The place to attach the chain is the letter “O” at the end of the name.
Accuracy in execution was achieved thanks to "drawing" with polygons - each line and vertex is created manually based on a sketch. I'll talk more about this a little later. Made entirely in 3ds max.
We will print on an FDM printer with PLA plastic. It is more fragile than analogues, but light and safe enough to make key chains out of it.
The second keychain is a stylized shield or triops, a freshwater crustacean, which at a favorable moment can be found in large puddles throughout most of the globe.
Shchitni (family Triopsidae), also known as sea men or sea monkeys, are small freshwater crustaceans that feed on plant debris and smaller living creatures. Harmless to humans, but can harm rice plantations by gnawing at the roots By itself, the shield is very interesting, for some even a beautiful arthropod. However, translating it into 3D, especially as a souvenir keychain, is not an easy task. Starting with the fact that the very appearance of arthropods, in principle, causes rejection among a part of the potential audience, and ending with the presence of subtle and small details.
For example, 70 pairs of legs, setae and antennae.
Therefore, one has to resort to simplification and stylization while maintaining the main features, and leveling the secondary ones.
(Now the slippers from crustatiologists - specialists in crustaceans will fly, for calling the species signs secondary) -))
Version codenamed “Simple A” The concept has undergone several changes: it was simplified, then more complicated, getting closer to the original and moving away from it. In the end, only 3 eyes remained from the shield, jointed tail abdomen, one and a half legs and, of course, the iconic shield that covers almost the entire body.
This model was sculpted in Zbrush. It is like no other program suitable for creating organic shapes.
Doesn't look like anything? And, by the way, Hans Rudi Giger was fond of biology and was generally a very erudite person. So I wouldn't be surprised if the shield was one of the sources of inspiration))) The second version of the shield - the base is the same, but the tail and underside of the body are worked out.
Still, for the sake of stylization and practicality, 65 out of 70 pairs of legs were removed, the shape of the end segments of the abdomen was changed to a more interesting one. All sharp edges are smoothed or directed inside the figure to reduce possible inconvenience.
The administrative staff of the project liked this concept so much that it will probably become a pendant - however, for this you will have to make a casting. To do this, a plastic model will be printed, on its basis a refractory metal casting mold will be made. Difficult, but doable.
Modeling is good - you can see how your product will look in different materials and with different lighting. Of course, in reality, many points will differ, but obviously stupid ideas can be discarded without spending effort and money.But the emblem of the community itself is good: laconic, understandable, reflects the prototype of the animal and symbolizes the tree of life. Therefore, it cannot be ignored either.
In addition to being stylish, it is also articulate.
True, not all - only the tail relative to the body, otherwise it will be too fragile on the scale of the keychain. I also made it in 3ds max, like the first one, but smoothed and changed in Zbrush. Yes, the transition was not necessary. But, oddly enough, the zebra loads the computer less. Well, in general, I'm more used to it.
By the way, it can be rotated in 3D in the browser: https://skfb.ly/ornsK
Phanerozoy charm for 3d printing by MilaHigher on Sketchfab
, of course, to get by with the internal means of rendering max and zebra, but in a keyshot it is more beautiful. In addition, it has good and realistic plastic shaders with subsurface scattering, which creates the effect of translucence at the edges. Love.
But not with key fobs. A shield with a ventral side, as mentioned above, may well become a pendant, for example. In addition, a phone stand with all sorts of Mesozoic living creatures is in the process.
