3D printing in medical field

3D printing in the medical field: four major applications revolutionising the industry

August 7, 2018updated 21 Jul 2022 8:14am

3D printing has many functions in a variety of industries, however, in the medical field it has four main applications. Allie Nawrat found out how this technology could be used to replace human organ transplants, speed up surgical procedures, produce cheaper versions of required surgical tools, and improve the lives of those reliant on prosthetic limbs.

By Allie Nawrat

3D printed organoid. Credit: Shutterstock.

Additive manufacturing, otherwise known as 3D printing, was first developed in the 1980s. It involves taking a digital model or blueprint of the subject that is then printed in successive layers of an appropriate material to create a new version of the subject.

The technique has been applied to (and utilised by) many different industries, including medical technology. Often medical imaging techniques, such as X-rays, computed tomography (CT) scans, magnetic resonance imaging (MRI) scans and ultrasounds are used to produce the original digital model, which is subsequently fed into the 3D printer.

It has been forecast that 3D printing in the medical field will be worth $3.5bn by 2025, compared to $713.3m in 2016. The industry’s compound annual growth rate is supposed to reach 17.7% between 2017 and 2025.

There are four core uses of 3D printing in the medical field that are associated with recent innovations: creating tissues and organoids, surgical tools, patient-specific surgical models and custom-made prosthetics.

Bioprinting tissues and organoids

One of the many types of 3D printing that is used in the medical device field is bioprinting. Rather than printing using plastic or metal, bioprinters use a computer-guided pipette to layer living cells, referred to as bio-ink, on top of one another to create artificial living tissue in a laboratory.

These tissue constructs or organoids can be used for medical research as they mimic organs on a miniature scale. They are also being trialled as cheaper alternatives to human organ transplants.

US-based medical laboratory and research company Organovo is experimenting with printing liver and intestinal tissue to help with the studying of organs in vitro, as well as with drug development for certain diseases. In May 2018, the company presented pre-clinical data for the functionality of its liver tissue in a programme for type 1 tyrosinemia, a condition that impedes the body’s ability to metabolise the amino acid tyrosine due to the deficiency of an enzyme.

The Wake Forest Institute in North Carolina, US, adopted a similar approach by developing a 3D brain organoid with potential applications in drug discovery and disease modelling. The university announced in May 2018 that it’s organoids have a fully cell-based, functional blood brain barrier that mimics normal human anatomy. It has also been working on 3D printing skin grafts that can be applied directly to burn victims.

Surgery preparation assisted by the use of 3D printed models

Another application of 3D printing in the medical field is creating patient-specific organ replicas that surgeons can be use to practice on before performing complicated operations. This technique has been proven to speed up procedures and minimise trauma for patients.

This type of procedure has been performed successfully in surgeries ranging from a full-face transplant to spinal procedures and is beginning to become routine practice.

“3D printing has been used to create patient-specific organ replicas that surgeons can be use to practice on before performing complicated operations.”

In Dubai, where hospitals have a mandate to use 3D printing liberally, doctors successfully operated on a patient who had suffered a cerebral aneurysm in four veins, using a 3D printed model of her arteries to map out how to safely navigate the blood vessels.

In January 2018, surgeons in Belfast successfully practiced for a kidney transplant for a 22-year-old woman using a 3D printed model of her donor’s kidney. The transplant was fraught with complications as her father, who was her donor, had an incompatible blood group and his kidney was discovered to have a potentially cancerous cyst. Using the 3D printed replica of his kidney, surgeons were able to assess the size and placement of the tumour and cyst.

3D printing of surgical instruments

Sterile surgical instruments, such as forceps, hemostats, scalpel handles and clamps, can be produced using 3D printers.

Not only does 3D printing produce sterile tools, some are based on the ancient Japanese practice of origami, meaning they are precise and can be made very small. These instruments can be used to operate on tiny areas without causing unnecessary extra damage to the patient.

One of the main benefits of using 3D printing rather than traditional manufacturing methods to produce surgical instruments is the production costs are significantly lower.

Custom-made prosthetics using 3D printing

3D printing in the medical field can be used to produce prosthetic limbs that are customised to suit and fit the wearer. It is common for amputees to wait weeks or months to receive prosthetics through the traditional route; however, 3D printing significantly speeds up the process, as well as creating much cheaper products that offer patients the same functionality as traditionally manufactured prosthetics.

The lower price point of these products makes them particularly applicable for use with children, who quickly outgrow their prosthetic limbs.

“3D printing can be used to produce prosthetic limbs that are customised.”

3D printing also allows the patient to design a prosthetic that corresponds directly to their needs. For example, Body Labs has created a system that allows patients to model their prosthetic on their own limbs through scanning in order to create a more natural fit and appearance. Plus, researchers at the Massachusetts Institute of Technology have sought to design more comfortable prosthetic sockets.

Introduction to Medical 3D Printing and 3D Printers for Healthcare

Personalized, precision medicine is on the rise. New tools and advanced technologies are bringing doctors closer to patients, delivering treatments and devices customized to better serve each unique individual.

Advances in medical 3D printing technology have made tremendous contributions to fields throughout healthcare. For patients, new tools and therapeutic methods developed through 3D printing can bring new degrees of comfort and personalization to treatment. For doctors, this newly accessible technology allows for a greater understanding of complex cases and provides new tools that can ultimately result in a higher standard of care.

From surgical planning models to 3D printed vasculature and bioreactors, read on to discover five ways 3D printing in healthcare is taking off and why many medical professionals are excited about the potential of 3D printing in the medical field. Then, learn about the most popular 3D printers for healthcare and how to choose a solution for specific use cases.

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3D printed anatomical models from patient scan data are becoming increasingly useful tools in today’s practice of personalized, precision medicine. As cases become more complex and operating room efficiency becomes more important for routine cases, visual and tactile reference models can enhance understanding and communication within OR teams and with patients.

Healthcare professionals, hospitals, and research organizations across the globe are using 3D printed anatomical models as reference tools for preoperative planning, intraoperative visualization, and sizing or pre-fitting medical equipment for both routine and highly complex procedures that have been documented in hundreds of publications.

Producing patient-specific, tactile reference models from CT and MRI scans is affordable and straightforward with 3D printing. Peer-reviewed literature shows that they provide an additional view that helps physicians prepare better for surgeries, leading to drastically reduced time and cost in the operating room while improving patient satisfaction, lowering anxiety, and reducing recovery time.

Physicians can use patient-specific surgical models to explain the procedure beforehand, improving patient consent and lowering anxiety.

Learning from preoperative models can influence the course of treatment as well. This was true of the experience of Dr. Michael Eames. After replicating a young patient’s forearm bones, Dr. Eames realized the injury differed from what he’d previously thought.

Dr. Eames settled on a new, soft-tissue procedure—one that was much less invasive, decreased rehabilitation time, and produced far less scarring. Using the printed bone replica, Dr. Eames walked the young patient and his parents through the procedure and obtained their consent.

The result? A surgery time of less than 30 minutes, instead of the initially planned surgery of three hours. This difference in surgery time led to an estimated $5,500 in cost avoidance for the hospital and meant the patient would need to spend less recovery time in postoperative care.

In the words of Dr. Alexis Dang, an orthopedic surgeon at the University of California San Francisco (UCSF) and the San Francisco Veteran's Affairs Medical Center: “Every one of our full-time orthopedic surgeons and nearly all of our part-time surgeons have utilized 3D printed models for care of patients at the San Francisco VA. We’ve all seen that 3D printing improves performance on game day.”

New biocompatible medical 3D printing materials have also enabled new surgical tools and techniques to be developed for the express purpose of further improving clinical experience during surgery. These include sterilizable fixation trays, contouring templates, and implant sizing models that can be used to size implants in the OR before the first cut, helping surgeons reduce time and increase accuracy of complex procedures.

Anatomical model of a hand, including the 'skin' made out of an elastic 3D printing material.

Todd Goldstein, PhD, Instructor at the Feinstein Institute for Medical Research, is unequivocal in his estimation of how central 3D printing technology has become to his department. He estimates that if Northwell uses 3D printed models in 10-15% of its cases, it could save $1,750,000 a year.

“From medical device prototypes, complicated anatomical models for our children’s hospital, to creating training systems, and finally entering the dental clinic with implant surgical guides, [3D printing technology] has increased our capabilities and decreased our costs, all while allowing us to provide tools to treat patients that would be next to impossible to replicate without our go-to SLA 3D printer,” said Goldstein.

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3D printing has virtually become a synonym for rapid prototyping. The ease of use and low cost of in-house 3D printing has also revolutionized product development and many manufacturers of medical tools have adopted the technology to produce brand new medical devices and surgical instruments.

Over 90 percent of the top 50 medical device companies use 3D printing to create accurate prototypes of medical devices, jigs and fixtures to simplify testing, as well as directly 3D printing medical devices.

In the words of Alex Drew, a mechanical project engineer at DJO Surgical, a global provider of medical devices. “Before DJO Surgical brought the [Formlabs 3D printer] on board, we relied almost exclusively on outside print vendors for prototypes. Today, we are running four Formlabs machines, and the impact has been profound. Our rate of 3D printing has doubled, cost has been reduced by 70 percent, and the level of print detail allows for clear communication of designs with orthopedic surgeons.”

Medical device companies like Coalesce use 3D printing to create accurate prototypes of medical devices.

3D printing can accelerate the design process by iterating complex designs in days instead of weeks. When Coalesce was tasked to create an inhaler device that can digitally assess an asthma patient’s inspiratory flow profile outsourcing to service providers would have resulted in lengthy lead times for each prototype. Design files would have had to be painstakingly refined through various iterations before being sent off-site to be built.

Instead, desktop SLA 3D printing allowed Coalesce to keep the entire prototyping process in-house. The prototypes were fit for use in clinical studies and looked just like a finished product. In fact, when they showcased the device, their clients mistook the prototype for the final product.

Overall, in-house represented an enormous 80–90% reduction in lead time for prototypes. What’s more, the parts took only eight hours to print and could be finished and painted within a few days, while the same process would have taken a week or two through an external contractor.

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Each year hundreds of thousands of people lose a limb, but only a subset of them get access to a prosthesis to recover its function.

Simple prostheses are only available in a few sizes, so patients must make do with what fits best, while custom-fit bionic devices designed to mimic the motions and grips of real limbs that rely on muscles in a person’s residual limb to control their functions are so expensive that they’re only accessible to patients with the best health insurance in developed countries. This particularly affects prostheses for children. As children grow and get into adventures, they inevitably outgrow their prostheses and require expensive repairs.

The difficulty is the lack of manufacturing processes that can produce custom parts affordably. But increasingly, prosthetists can take advantage of 3D printing’s much-noted design freedom to mitigate these high financial barriers to treatment.

Initiatives such as e-NABLE allow entire communities around the world to form around 3D printed prostheses. They’re driving an independent movement in prosthetic production by sharing information and open-source designs freely online, so patients can get a custom-designed prosthesis that is well-adapted for them for as little as $50.

Other inventors like Lyman Connor, take this one step further. With only a small facility of four desktop 3D printers, Lyman was able to complete and fit his first production prostheses. His ultimate objective? To create a customizable, fully bionic hand to be sold at a fraction of the current tens of thousands of dollars retail price tag for such advanced prostheses.

Elsewhere, researchers at MIT have also identified 3D printing as an optimal means of producing more comfortable prosthesis sockets.

Needless to say, the low cost of producing these prostheses, along with the freedom that comes with custom designs, has proved revelatory. Prostheses made with 3D printing can be turned around in as little as two weeks and then can be trialed and maintained at a much lower cost than their traditional counterparts.

As the costs continue to decrease and material properties improve, 3D printing will undoubtedly play an increasing role in this department of healthcare.

Many of the same high financial barriers to treatment seen in prosthetics are also native to fields such as orthoses and insoles. Like many other patient-specific medical devices, custom orthoses are often inaccessible due to their high cost and take weeks or months to get manufactured. With 3D printing, that no longer needs to be the case.

The example of Matej and his son Nik springs to our mind. Born prematurely in 2011, difficulties during childbirth caused Nik to have cerebral palsy, a condition that affects almost twenty million people worldwide. Matej was inspired by his son’s unwavering will to transcend the limitations of his condition, but he was faced with a choice between a standard, pre-made orthosis that would have been inadequate and uncomfortable for his son, or an expensive custom solution that would take weeks or months to be delivered, only to be made quickly obsolete by a growing child.

He decided to take matters into his own hands and sought out new solutions to achieve this goal. With the freedom offered by digital technologies including 3D scanning and 3D printing, Matej and Nik's physical therapists were able to experiment liberally and develop an entirely new innovative workflow for ankle foot orthoses (AFOs).

The resulting custom-made, 3D printed orthosis provided Nik with support, comfort, and correction precisely where it was needed, helping Nik to at last take his first independent steps. This custom orthotic device reprised the highly-adjusted finish of high-end orthotics, at a fraction of the price, and with no further adjustments required.

Professionals around the world are using 3D printing to reinvent patient- and customer-specific insoles and orthoses, as well as a range of other tools for improving physical therapy. In the past, the course of physical therapy using customized tools had proved difficult. Patients often faced long wait times and finished pieces that led to discomfort. 3D printing is on the path to change this status quo. 3D printed insoles and orthoses have proved to be a better fit, led to better therapeutic outcomes, and provided a greater degree of comfort and use for patients.

The conventional means of treating patients with grave organ failures currently involve using autografts, a graft of tissue from one point to another of the same individual's body, or organ transplants from a donor. Researchers in the fields of bioprinting and tissue engineering are hoping to soon change that and be able to create tissues, blood vessels, and organs on demand.

3D bioprinting refers to the use of additive manufacturing processes to deposit materials known as bioinks to create tissue-like structures that can be used in medical fields. Tissue engineering refers to the various evolving technologies, including bioprinting, to grow replacement tissues and organs in the laboratory for use in treating injury and disease.

With the help of high-precision 3D printing, researchers like Dr. Sam Pashneh-Tala from the University of Sheffield have brought new possibilities to tissue engineering.

To direct cellular growth so that the required tissue is formed, Dr. Pashneh-Tala grows living cells on a scaffold in the lab, that provides a template of the required shape, size, and geometry. For example, a tubular structure is needed to create a blood vessel for a cardiovascular patient. The cells will multiply and cover the scaffold, taking on its shape. The scaffold then gradually breaks down, leaving the living cells arranged into the shape of the target tissue, that is cultured in a bioreactor, a chamber that contains the developing tissue and can reproduce the internal environment of the body, to acquire mechanical and biological performance of organic tissue.

A 3D printed bioreactor chamber with a tissue-engineered miniature aorta growing inside. The tissue is cultured in the bioreactor to acquire the mechanical and biological performance of organic tissue.

This will empower scientists to create patient-specific vascular graft designs, improved surgical options and provides a unique testing platform for new vascular medical devices for those suffering from cardiovascular disease, that is currently the number one cause of death worldwide. Following that, the ultimate goal is to create blood vessels that are ready to be implanted into the patients. As tissue engineering uses cells that are taken from the patient requiring the treatment, it eliminates the possibility of rejection by the immune system—a major issue in conventional organ transplant procedures today.

3D printing has proven capable of responding to the challenges of producing synthetic blood vessels by solving the difficulties of recreating the precise shapes, sizes and geometries of the vessel required. Being able to closely match printed solutions to the specific needs of patients has proved revelatory.

In Dr. Pashneh-Tala’s words: “[Creating blood vessels through 3D printing] offers the potential for improved surgical options and even patient-matched blood vessel designs. Without access to high-precision, affordable 3D printing, creating these shapes would not be possible.”

We have seen exciting breakthroughs in biological materials suitable for use in 3D printers. Scientists are developing new hydrogel materials that have the same consistency as organ tissue that can be found in the human brain and lungs and can be compatible with various 3D printing processes. Scientists are hoping to be able to implant them onto an organ, to act as ‘scaffold’ onto which cells would be encouraged to grow.

While bioprinting fully functional internal organs such as hearts, kidneys, and livers still sounds futuristic, advancements with hybrid 3D printing techniques are happening at a very rapid rate.

Sooner or later, building biological matter in laboratory printers is expected to lead to the ability to generate new, fully functional 3D printed organs. In April 2019, scientists created the first 3D heart using a patient's biological materials at Tel Aviv University. The tiny replica was created using the patient’s own biological materials, engendering a complete match of the patient’s immunological, cellular, biochemical, and anatomical profile.

"At this stage, our 3D heart is small, the size of a rabbit's heart, but larger human hearts require the same technology," said Professor Tal Dvir.

The first 3D bioprinted heart, created at the University of Tel Aviv.

When it comes to 3D printers for healthcare, not all methods are created equal. It is important to choose the right printing technology for specific use cases.

The most popular medical 3D printing technologies include stereolithography (SLA), selective laser sintering (SLS), and fused deposition modeling (FDM) for plastic parts, and direct metal laser sintering (DMLS) and selective laser melting (SLM) for metals.

SLA 3D printers use a laser to cure liquid resin into hardened plastic in a process called photopolymerization. SLA is one of the most popular processes among medical professionals due to its high resolution, precision, and material versatility.

Advantages of SLA

SLA parts have the highest resolution and accuracy, the clearest details, and the smoothest surface finish of all plastic 3D printing technologies. The main benefit of SLA, however, lies in its versatility. SLA resin formulations offer a wide range of optical, mechanical, and thermal properties to match those of standard, engineering, and industrial thermoplastics.

SLA is a great option for highly detailed anatomical models, medical device prototypes requiring tight tolerances and smooth surfaces, as well as molds, tooling, patterns, and functional end-use parts. SLA also offers the widest selection of biocompatible materials for dental and medical applications. With Draft Resin, the Formlabs SLA printers are also the fastest options for 3D printing large prototypes, up to 10X faster than FDM.

SLA’s wide versatility comes with a slightly higher price tag than FDM, but it is still more affordable than all other 3D printing processes. SLA resin parts also require post-processing after printing, which includes washing the parts and post-curing.

SLA 3D printing offers a wide selection of 3D printing materials, including biocompatible materials, for a variety of medical and dental applications.

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SLS 3D printers use a high-powered laser to fuse small particles of polymer powder. The unfused powder supports the part during printing and eliminates the need for dedicated support structures, making SLS a particularly effective choice for complex mechanical parts.

Its ability to produce parts with excellent mechanical capabilities makes SLS the most common polymer additive manufacturing technology for industrial applications. Depending on the material, SLS nylon parts may also be biocompatible and sterilizable.

Advantages of SLS

Since SLS printing doesn’t require dedicated support structures, it’s ideal for complex geometries, including interior features, undercuts, thin walls, and negative features. Parts produced with SLS printing have excellent mechanical characteristics, with strength resembling that of injection-molded parts.

The most common material for SLS is nylon, a popular engineering thermoplastic with excellent mechanical properties. Nylon is lightweight, strong, and flexible, as well as stable against impact, chemicals, heat, UV light, water, and dirt. 3D printed nylon parts can also be biocompatible and not sensitizing, which means that they are ready to wear and safe to use in many contexts.

The combination of low cost per part, high productivity, established materials, and biocompatibility makes SLS a popular choice among medical device developers for functional prototyping, and a cost-effective alternative to injection molding for limited-run or bridge manufacturing.

SLS 3D printers have a higher entry price than FDM or SLA technologies. While nylon is a versatile material, material selection for SLS is also more limited than for FDM and SLA. Parts come out of the printer with a slightly rough surface finish and require media blasting for a smooth finish.

SLS 3D printing is ideal for strong, functional prototypes and end-use parts, such as prosthetics and orthotics.

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FDM, also known as fused filament fabrication (FFF), is a printing method that builds parts by melting and extruding thermoplastic filament, which a printer nozzle deposits layer by layer in the build area.

FDM is the most widely used form of 3D printing at the consumer level, fueled by the emergence of hobbyist 3D printers. Industrial FDM printers are, however, also popular with professionals.

Advantages of FDM

FDM works with an array of standard thermoplastics, such as ABS, PLA, and their various blends. This results in a low price of entry and materials. FDM best suits basic proof-of-concept models and the low-cost prototyping of simpler parts. Some FDM materials are also biocompatible.

FDM has the lowest resolution and accuracy when compared to other 3D printing technologies for plastics such as SLA or SLS, which means that it is not the best option for printing complex designs or parts with intricate features, such as anatomical models. Higher-quality finishes require labor-intensive and lengthy chemical and mechanical polishing processes. Some industrial FDM 3D printers use soluble supports to mitigate some of these issues and offer a wider range of engineering thermoplastics, but they also come at a steep price. When creating large parts, FDM printing also tends to be slower than SLA or SLS.

Direct metal laser sintering (DMLS) and selective laser melting (SLM) 3D printers work similarly to SLS printers, but fuse metal powder particles together layer by layer using a laser instead of polymers.

DMLS and SLM 3D printers can create strong, accurate, and complex metal products, making this process ideal for a variety of medical applications.

The biggest advantage of these processes is obviously the materials, as DMLS and SLM 3D printers are capable of producing high-performing end-use medical devices and components from metal. These processes can reproduce complex geometries and the finished products are strong, durable, and biocompatible. They can be used to manufacture generic implants (hips, knees, spine implants, etc.), custom implants for cancer or trauma treatment, dentures, as well as medical and orthopedic technology products.

While the prices of metal 3D printers have also begun to decrease, with costs ranging from $200,000 to $1 million+, these systems are still not accessible to most businesses. Metal 3D printing processes also have an involved and complex workflow.

Alternatively, SLA 3D printing is well-suited for casting workflows that produce metal parts at a lower cost, with greater design freedom, and in less time than traditional methods.

The table below highlights the 3D printing technologies that are best equipped to handle the different medical 3D printing applications.

	Stereolithography (SLA)	Selective Laser Sintering (SLS)	Fused Deposition Modeling (FDM)	Metal 3D Printing (DMLS, SLM)
Build volume	Up to 300 x 335 x 200 mm (desktop and benchtop 3D printers)	Up to 165 x 165 x 300 mm (benchtop industrial 3D printers)	Up to 300 x 300 x 600 mm (desktop and benchtop 3D printers)	Up to 400 x 400 x 400 mm (large industrial DMLS/SLM)
Price range	Starting from $3,750	Starting from $18,500	Starting from $2,500	Starting from $200,000
Materials	Varieties of resin (thermosetting plastics). Standard, engineering (ABS-like, PP-like, silicone-like, flexible, heat-resistant, rigid), castable, dental, and medical (biocompatible).	Engineering thermoplastics, typically nylon and its composites (nylon is biocompatible + compatible with sterilization).	Standard thermoplastics, such as ABS, PLA, and their various blends.	Stainless steel, tool steel, titanium, cobalt chrome, and aluminum.
Ideal applications	Anatomical models, highly detailed prototypes requiring tight tolerances and smooth surfaces; molds, tooling, patterns, functional parts, dental and medical end-use devices.	Complex geometries, functional prototypes, short-run or bridge manufacturing of medical devices, including orthotics and prosthetics.	Basic proof-of-concept models, low-cost prototyping of simple parts.	Strong, durable parts with complex geometries, implants, dentures, medical and orthopedic components out of metal.

Precise and affordable medical 3D printing processes are democratizing access to the technology, empowering healthcare professionals to develop new clinical solutions and quickly manufacture custom devices, and allowing physicians to deliver new treatments across the globe. As medical 3D printing technologies and materials continue to improve, they will pave the path for personalized care and high-impact medical applications.

Every medical facility should have access to the latest tools to improve care and provide the best patient experience. Get started now or expand your in-house production with Formlabs, a proven, cutting-edge partner in medical 3D printing.

Reach out to our medical experts to learn more about how in-house 3D printing can provide better treatment and supplement your current medical device design and manufacturing workflow.

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5 Innovative Medical Applications for 3D Printing

Personalized and precise medical solutions are gaining popularity. New tools and advanced technologies bring doctors closer to patients by providing treatments and devices that meet the needs of each individual.

The expansion of 3D printing technology in healthcare has made a huge contribution to improving the quality of medical services. With new tools and treatment approaches developed using 3D printing, patients feel that their treatment becomes more comfortable and personal. For physicians, the new technology available allows them to better analyze complex cases and provides new tools that can ultimately raise standards of care.

Later in this article, you'll learn about five areas, from models for surgical planning to vascular systems and bioreactors, in which 3D printing is used in healthcare, and why many healthcare professionals see great potential in this technology.

In today's medical practice, 3D printed anatomical models based on patient body scans are becoming more indispensable tools, as they provide more personalized and accurate treatment. As cases become more complex and standard case times become more important, visual and tactile anatomical models are helping surgeons to better understand their task, communicate more effectively, and communicate with patients more easily.

Medical professionals, hospitals and research institutions around the world use 3D printed anatomical models as a reference tool for preoperative planning, intraoperative imaging, and for sizing medical instruments or presetting equipment for both standard and very complex procedures, which is reflected in hundreds of scientific publications.

3D printing makes 3D printing affordable and easy to create customized patient anatomical models based on CT and MRI data. The peer-reviewed scientific literature demonstrates that they help clinicians better prepare for surgery, resulting in significant cost and time savings. At the same time, patient satisfaction is also increased through reduced anxiety and reduced recovery time.

Physicians can use individual patient anatomical models to explain the procedure to the patient, making it easier to obtain patient consent and reduce patient anxiety.

Preparation for surgery using preoperative models can also affect the effectiveness of the treatment. The experience of Dr. Michael Ames confirms this. After obtaining bone replications from the young patient's forearm, Dr. Ames realized that the injury was different from what he expected.

Based on this information, Dr. Ames chose a new soft tissue procedure that was much less invasive, reduced downtime, and resulted in much less scarring. Using imprinted bone replication, Dr. Ames explained the procedure to the young patient and his parents and obtained their consent.

Physicians can use patient-specific surgical models to explain the procedure beforehand, improving patient consent and lowering anxiety.

Result? The operation lasted less than 30 minutes instead of the originally planned three hours. With this reduction in operating time, the hospital avoided a cost of about $5,500 and the patient recovered faster.

According to Dr. Alexis Dang, Orthopedic Surgeon at UC San Francisco and Veterans Affairs Medical Center San Francisco: “All of our full-time orthopedic surgeons and nearly all of our full-time surgeons part-time, used 3D printed models to treat patients at a Veterans Medical Center in San Francisco. We could all see that 3D printing improves the efficiency of our work.”

The advent of new biocompatible medical polymers for 3D printing has opened up opportunities for the development of new surgical instruments and techniques to further improve clinical operating procedures. These include sterilizable trays, contoured surgical guides, and implant models that can be used to determine the size of an implant prior to surgery, helping surgeons reduce time and improve accuracy in complex procedures.

Anatomical model of a hand with elastic polymer skin for 3D printing.

Todd Goldstein, PhD, lecturer at the Feinstein Institute for Medical Research, is unequivocal about the importance of 3D printing technology to the work of his department. He estimates that if Northwell used 3D-printed models 10-15% of the time, it could save $1,750,000 a year.

“Whether it's prototyping medical devices, complex anatomical models for our children's hospital, designing training systems, or making surgical templates for dental clinics, [3D printing technology] has increased our capabilities and reduced our costs in a variety of areas. In doing so, we were able to produce instruments for treating patients that would be almost impossible to recreate without our sought-after stereolithography 3D printer,” says Goldstein.

3D printing has become virtually synonymous with rapid prototyping. The ease of use and low cost of 3D printing in-house has also revolutionized product development, with many medical instrument manufacturers adapting the technology to produce entirely new medical devices and surgical instruments.

Over 90 percent of the top 50 medical device companies use 3D printing to create accurate medical device prototypes and fixtures and fittings to simplify testing.

According to Alex Drew, Principal Mechanical Engineer at DJO Surgical, an international medical device supplier, “Before DJO Surgical purchased [Formlabs' 3D printer], we printed nearly all of our prototypes outsourced. Today we are working with four Formlabs printers and are very pleased with the results. The speed of 3D printing has doubled, the cost has been reduced by 70%, and the level of detail allows you to effectively coordinate designs with orthopedic surgeons.

Medical companies such as Coalesce are using 3D printing to create accurate medical device prototypes.

3D printing helps speed up the design process by allowing complex designs to be iterated over in days instead of weeks. When Coalesce was tasked with building an inhaler device that could digitally evaluate an asthma patient's inspiratory flow profile, outsourcing would result in a significant increase in production time for each prototype. Before sending the project files to a third party company for the physical implementation of the project, they would have to be carefully developed and carried through various iterations.

Instead, desktop stereolithographic 3D printing allowed Coalesce to handle the entire prototyping process in-house. The prototypes were suitable for use in clinical trials and looked just like the finished product. Moreover, when the company demonstrated the device, its customers mistook the prototype for the final product.

Overall, the introduction of in-house manufacturing resulted in an exceptional reduction in prototyping time by 80–90%. In addition, the models took only eight hours to print and were finished and painted in a matter of days, while outsourcing the same process would take a week or two.

Hundreds of thousands of people lose limbs every year, but only a fraction of them are able to restore limb function with a prosthesis.

Conventional dentures are only available in a few sizes, so patients must adjust to what fits best. On the other hand, custom bionic prostheses that mimic the movements and grips of a real limb based on the impulses of the surviving limb muscles are so expensive that they can only be used by patients living in developed countries with the best medical insurance. In the case of children's prostheses, the situation is aggravated even more. Children grow up and inevitably outgrow their prostheses, which, as a result, require costly modifications.

The difficulty lies in the lack of manufacturing processes that would allow for individual orders at an affordable price. But increasingly, prosthetists are looking to reduce these high financial barriers to rehabilitation with the flexible design capabilities of 3D printing.

Initiatives like e-NABLE allow people around the world to learn about the possibilities of 3D printed prostheses. They are driving an independent movement in the prosthesis industry by offering information and free open source projects so that patients can get a custom-designed prosthesis for as little as $50.

Other inventors, such as Lyman Connor, go even further. With only a small fleet of four desktop 3D printers, Lyman was able to fabricate and customize his first mass-produced prostheses. His ultimate goal? Create a customizable fully bionic arm that will cost incomparably less than similar prostheses that retail for tens of thousands of dollars.

Researchers at the Massachusetts Institute of Technology have also found that 3D printing is the best method for making more comfortable prosthetic sockets.

In addition, the low cost of manufacturing these prostheses, as well as the freedom that comes with being able to design custom designs, speak for themselves. 3D printed prostheses have a lead time of just two weeks, and then they can be tried and serviced at a much lower cost than traditional counterparts.

As costs continue to fall and material properties improve, the role of 3D printing in healthcare will no doubt become more important.

The same high financial barriers that are seen in prosthetics are common in orthoses and insoles. Like many other patient-specific medical devices, custom orthoses are often not available due to their high cost and take weeks or months to manufacture. 3D printing solves this problem.

Confirmation is the example of Matej and his son Nick. Nick was born in 2011. Complications during preterm birth led to the fact that he developed cerebral palsy, a pathology that affects nearly twenty million people worldwide. Matei admired how determined his son was to overcome the limitations of his illness, but he was faced with a choice between a standard, off-the-shelf orthosis that would be uncomfortable for his son, or an expensive custom solution that would take weeks or months to manufacture and ship. , and from which the child would quickly grow.

He decided to take matters into his own hands and began to look for new ways to achieve his goal. Thanks to the opportunities provided by digital technologies, in particular 3D scanning and 3D printing, Matei and Nika's physiotherapists were able to develop a completely new innovative workflow for the manufacture of ankle orthoses through experiments.

The resulting 3D-printed, custom-fit orthosis that provides support, comfort, and motion correction helped Nick take his first steps on his own. This non-standard orthopedic device reproduced the functionality of the highest-class orthopedic products, at the same time it cost many times less and did not require any additional settings.

Professionals around the world are using 3D printing as a new method of manufacturing custom insoles and orthoses for patients and clients, as well as a range of other physiotherapy tools. In the past, undergoing a course of physiotherapy with the use of individual physiotherapy instruments carried many difficulties. Often there was a situation when patients had to wait a long time for a finished product, which at the same time did not provide proper comfort. 3D printing is step by step changing this status quo. Data confirms that 3D printed insoles and orthoses offer a more precise fit and lead to better therapeutic outcomes, which means greater comfort and benefit for patients.

The usual treatments for patients with severe organ damage today are autografts, transplantation of tissue from one area of the body to another, or transplantation of a donor organ. Researchers in bioprinting and tissue engineering hope to expand this list soon with on-demand fabrication of tissues, blood vessels, and organs.

3D bioprinting is an additive manufacturing process that uses materials known as bioink (a combination of living cells and a compatible substrate) to create tissue-like structures that can be used in medicine. Tissue engineering combines new technologies, including bioprinting, which make it possible to grow replacement tissues and organs in the laboratory for use in the treatment of injuries and diseases.

Using high-precision 3D printing, researchers such as Dr. Sam Pashne-Tala from the University of Sheffield are breaking new ground in tissue engineering.

In order to direct cell growth to form the necessary tissue, Dr. Pashne-Tala grows living cells on a laboratory scaffold that provides a template of the required shape, size and geometry. For example, to create a blood vessel for a patient with cardiovascular disease, a tubular structure is needed. The cells will multiply and cover the scaffold, taking on its shape. Then the scaffold is gradually destroyed, and the living cells take the form of the target tissue, which is cultured in a bioreactor - a chamber that contains the cultured tissue and can reproduce the internal environment of the body so that the cultured tissue acquires the mechanical and biological characteristics of organic tissue.

3D printed bioreactor chamber with tissue engineered aorta miniature inside. The tissue is cultured in a bioreactor to acquire the mechanical and biological characteristics of the organic tissue.

This will allow scientists to design patient-specific vascular grafts, expand surgical care, and provide a unique platform for testing new vascular medical devices for people suffering from cardiovascular disease, which is currently the leading cause of death worldwide. The ultimate goal is to create blood vessels that are ready for implantation in patients. Since tissue engineering uses cells taken from a patient in need of treatment, this eliminates the possibility of rejection by the immune system, which is the main problem of modern transplantation.

3D printing has proven its ability to solve the problems that exist in the production of synthetic blood vessels, in particular, the difficulty of recreating the required accuracy of the shape, size and geometry of the vessel. The ability of printed solutions to clearly reflect the specific characteristics of patients was a step forward.

According to Dr. Pashne-Tal: “[Creating blood vessels using 3D printing] makes it possible to expand the possibilities of surgical care and even create designs of blood vessels for a specific patient. Without the existence of high-precision affordable 3D printing, the creation of such forms would not be possible.”

We are witnessing significant advances in the development of biological materials that can be used in 3D printers. Scientists are developing new hydrogel materials that have the same consistency as organ tissues present in the human brain and lungs, which can be used in a range of 3D printing processes. Scientists hope that they will be able to implant them into the body as a "scaffold" for cell growth.

Although bioprinting of fully functional internal organs such as the heart, kidneys and liver still looks futuristic, hybrid 3D printing at very high speed opens up more and more new horizons.

It is expected that sooner or later the creation of biological matter on laboratory printers will lead to the generation of new, fully functional 3D printed organs. In April 2019, scientists at Tel Aviv University 3D-printed the first heart using biological tissue from a patient. A tiny copy was created using the patient's own biological tissues, which made it possible to fully match the immunological, cellular, biochemical and anatomical profile of the patient.

“At this stage, the heart we printed is small, about the size of a rabbit heart, but normal-sized human hearts require the same technology,” says Prof. Tal Dvir.

The first 3D bioprinted heart created at Tel Aviv University.

Precise and affordable 3D printing processes, such as desktop stereolithography, are democratizing access to technology, enabling healthcare professionals to develop new clinical solutions and quickly produce medical devices with individual characteristics, and doctors around the world to offer new types of therapy.

As 3D printing technologies and materials improve, it will continue to expand personalized treatment and deliver high performance medical devices.

Learn more about the use of 3D printing in healthcare

How 3D printing is used in domestic medicine: successful examples and developments

How do additive technologies help doctors and hospitals work? For what areas are 3D printing technologies used in our country? Consider the example of successful cases of their use in Russian medicine.

The use of 3D printing in world practice

For the first time, additive technologies in medicine were officially used in 1999, when employees of the American Institute for Regenerative Medicine Wake Forest implanted an organ made using computed tomography and a 3D printer into a human.

Now 3D printing in medicine is a rather extensive list of directions and possibilities. Among them are:

creation of implants;
bone seal;
simulation of human internal organs;
creation of medical instruments for doctors.

3D printing in medicine makes it possible to model and create dental implants, prostheses, and organ prototypes with high accuracy. Also, 3D printing helps already working specialists and doctors to study and improve their skills more effectively, practice and make accurate plans for surgical operations.

With the advent of new, more and more advanced printing devices and the expansion of the list of materials, additive technologies in medicine are developing more and more rapidly. The most active 3D printing is used in the USA.

For example, in 2019, a 3D-printed finger bone was transplanted to a Florida patient for the first time. And University of Kentucky radiology and cardiology professor Michael Winkler has created a 3D printed model of the heart that doctors can work with. Such organ prototypes help surgeons plan operations more accurately and increase the chances of a patient's quick recovery.

How are medical

3D technologies developing in Russia?

There are a number of successful companies in Russia that produce devices and materials for 3D printing, develop additive technologies in various industries (among them are PICASO 3D, Imprinta, Anisoprint, Tsvetnoy Mir, and many others). Domestic medicine has also achieved considerable success in terms of the use of 3D technologies.

For example, back in 2016 in Nizhny Novgorod, specialists from the Federal State Budgetary Institution "PFMIC" of the Ministry of Health of Russia performed two successful surgical interventions, during which they implanted prostheses for the hip joints printed on a 3D printer.

Since 2015, the hospital at the St. Petersburg State Pediatric Medical University has been performing heart surgeries, which are planned on 3D-printed organ prototypes. An important characteristic of such objects is that they are modeled taking into account all the anatomical features of a person and help surgeons perform the necessary procedures more quickly and accurately. In the treatment of heart defects, this reduces the time of the operation and reduces the risk of complications.

More information about how additive technologies are used in modern Russian medicine can be found in the report of Roman Gorbatov, head of the PIMU Laboratory of Additive Technologies, who will speak at the seventh 3D Print Expo on October 4.

Russian "bone cement"

for the treatment of fractures

Scientists from around the world are working on the invention of the optimal material for 3D printing of bones. So, researchers from the US Northwestern University in 2016 came up with an elastic and at the same time durable material for this. Russian specialists have developed a fabric that can become an alternative to titanium implants.

Specialists from the National Research Nuclear University have created a biocompatible material for printing bones with the human body. It is based on the composition of animal bones, so it is not rejected when implanted. The material is quite plastic, but quickly hardens, and then gradually dissolves: the body manages to heal the damage quickly and without side inflammatory processes.

This significantly speeds up the treatment process, reduces the risk of complications and eliminates the need for a second operation, as with titanium implants, which must be removed after a while.

This technology is implemented as follows: biocement is loaded into a 3D printer, and the damaged bone is scanned. Based on the information received, a three-dimensional model of the fragment to be printed is designed. The implant is made according to an exact design from bone cement loaded into the printer, and the material solidifies right during manufacturing, becoming strong and hard.

Prospects for 3D-printed

technologies in Russian medicine

Rusatom – Additive Technologies, which acts as the main industry integrator uniting several enterprises, specializes in the development of the additive direction in Russia. In 2020, RusAT plans to start producing 3D printed medical implants. Aleksey Dub, CEO of the company, claims that, in addition, the corresponding software will be created.

The project is currently being developed at the State Scientific Center of the Russian Federation TsNIITMASH, one of the institutes of Rosatom. The final product is an SLM printer with a three-axis optical system that will print objects using metal powder smelting technology.